Hydrochloric Acid → HCID 20551770, compound

HRID 1446951Notes

Reaction equation

HRID 1446951 reaction equation
[CH3:1][O:2][C:3]([C:6]1[S:10][C:9]([NH:11][C:12](=[O:21])[N:13]([CH2:15][CH:16](OC)[O:17]C)[CH3:14])=[N:8][N:7]=1)([CH3:5])[CH3:4].Cl>O>[CH3:1][O:2][C:3]([C:6]1[S:10][C:9]([N:11]2[CH:16]([OH:17])[CH2:15][N:13]([CH3:14])[C:12]2=[O:21])=[N:8][N:7]=1)([CH3:5])[CH3:4]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 20551768HCID 20551768, compound

Product 1

HCID 20551770HCID 20551770, compoundYield 71.6%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To the 4.9 grams of the 3-[5-[1-methoxy-1-methylethyl]-1,3,4-thiadiazol-2-yl]-1-methyl-(2,2-dimethoxyethyl)urea (prepared above) was added 150 milliliters of water and 1.5 milliliters of concentrated hydrochloric acid (HCl). The resulting solution was refluxed for 5 minutes, and the aqueous phase was extracted twice with 50 milliliters of chloroform (CHCl3). The 100 milliliter chloroform extract was dried over anhydrous MgSO4, filtered and topped on a roto-vac at 70° C. to yield 3.0 grams of a yellow oil of 3-[5-(1-methoxy-1-methylethyl)-1,3,4-thiadiazol-2-yl]-1-methyl-4-hydroxy-2-imidazolidinone with an

Workup

  1. temperatureThe resulting solution was refluxed for 5 minutes
  2. extractionthe aqueous phase was extracted twice with 50 milliliters of chloroform (CHCl3)
  3. extractionThe 100 milliliter chloroform extract
  4. dry with materialwas dried over anhydrous MgSO4
  5. filtrationfiltered
  6. customtopped on a roto-vac at 70° C.

Sources & evidence

ORD record
ord-e9c1e403520d442bb81021daa9de0b4b
Source dataset
uspto-grants-1982_02
Patent number
US04314842

Reaction notes

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