Methyl isothiocyanate → HCID 178486100, compound

HRID 1446990Notes

Reaction equation

HRID 1446990 reaction equation
[NH:1]([C:5]1[O:6][CH:7]=[C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([NH2:16])[CH:11]=2)[N:9]=1)[C:2]([NH2:4])=[NH:3].[CH3:17][N:18]=[C:19]=[S:20]>CN(C)C=O>[NH:1]([C:5]1[O:6][CH:7]=[C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([NH:16][C:19]([NH:18][CH3:17])=[S:20])[CH:11]=2)[N:9]=1)[C:2]([NH2:4])=[NH:3]

Participants

4

Reactant 2

HCID 11167Methyl isothiocyanateHCID 178512610HCID 178512610, compound

Product 1

HCID 178486100HCID 178486100, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Reaction of 2-guanidino-4-(3-aminophenyl)-oxazole with methylisothiocyanate in dimethylformamide gave 2-guanidino-4-[3-(3-methylthioureido)phenyl]oxazole having the following n.m.r. in d6DMSO: 2.8(d,4H); 3.25(s,H2O); 6.9(s,4H); 7.2-7.7(m,5H); 7.8(s,1H); 9.5(s,1H).

Sources & evidence

ORD record
ord-fb749f3e01ae4402ac8b24663dc048cf
Source dataset
uspto-grants-1982_02
Patent number
US04315009

Reaction notes

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