反应详情

0.48 g. (2.0 mmoles) of 5-bromo-tryptamine and 0.30 g. (2.3 mmoles) of 2-ethyl-pentanolide are dissolved in 5 ml. of abs. xylene, and the solution is refluxed for 4 hours. The reaction mixture is evaporated in vacuo, the residue is triturated twice with 3 ml. each of petroleum ether, thereafter it is dried in a desiccator. 0.59 g. (80%) of N-(α-ethyl-δ-hydroxy-valeroyl)-5-bromo-tryptamine are obtained.

1. customThe reaction mixture is evaporated in vacuo
2. customthe residue is triturated twice with 3 ml
3. dry with materialeach of petroleum ether, thereafter it is dried in a desiccator