Ammonia → HCID 10081198, compound

HRID 1447010Notes

Reaction equation

HRID 1447010 reaction equation
[CH2:1]([N:10]1[CH:14]=[N:13][CH:12]=[N:11]1)[C:2]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)=[O:3].[BH4-].[Na+].[Cl-].[NH4+].Cl.N>CO>[C:4]1([CH:2]([OH:3])[CH2:1][N:10]2[CH:14]=[N:13][CH:12]=[N:11]2)[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

Participants

7

Reactant 5

HCID 222AmmoniaHCID 313Hydrochloric AcidHCID 25517Ammonium ChlorideHCID 27648091-phenyl-2-(1H-1,2,4-triazol-1-yl)ethanoneHCID 4311764Sodium borohydride

Product 1

HCID 10081198HCID 10081198, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

30 parts by weight of 1-phenacyl-1,2,4-triazole is dissolved in 300 parts by weight of methanol; at 5° to 10° C., 5 parts by weight of sodium borohydride is added in portions. After the mixture has been brought to room temperature, about 20 parts by weight of ammonium chloride is added, and the mixture is acidified with dilute hydrochloric acid, heated to boiling, made alkaline with ammonia, and evaporated. The solid residue is slurried with water. Filtration gives 27.5 parts by weight of 1-[2-phenyl-2-hydroxyethyl]-1,2,4-triazole.

Workup

  1. additionis added
  2. temperatureheated
  3. customevaporated
  4. filtrationFiltration

Sources & evidence

ORD record
ord-4c3c6ac1dbbe4c34a55cdc2c5a548afa
Source dataset
uspto-grants-1982_02
Patent number
US04315017

Reaction notes

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