Acetyl chloride → HCID 20495221, compound

HRID 1447018Notes

Reaction equation

HRID 1447018 reaction equation
[CH:1](=[O:5])[CH:2]([CH3:4])[CH3:3].[C:6](Cl)(=O)[CH3:7].[NH:10]1[CH:14]=[N:13][CH:12]=[N:11]1>C(#N)C.[Cu]>[N:10]1([CH:1]([O:5][CH2:6][CH3:7])[CH:2]([CH3:4])[CH3:3])[CH:14]=[N:13][CH:12]=[N:11]1

Participants

6

Reactant 3

HCID 6367Acetyl chlorideHCID 6561IsobutyraldehydeHCID 92571H-1,2,4-Triazole

Product 1

HCID 20495221HCID 20495221, compound

Reagents, catalysts & solvents 2

HCID 23978CopperCatalystHCID 6342AcetonitrileSolvent

Procedure

The diethylacetal of iso-butyraldehyde (2.8 g) was reacted with acetyl chloride (2.7 g) in the presence of copper bronze; the product was reacted with 1,2,4-triazole (3.0 g) in acetonitrile (50 ml) to give the title compound as a viscous oil which GLC showed to be slightly impure.

Sources & evidence

ORD record
ord-3e304f77bc3e4003babf148aa728ffd0
Source dataset
uspto-grants-1982_02
Patent number
US04315016

Reaction notes

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