Hydrochloric Acid → HCID 12761772, compound

HRID 1447028Notes

Reaction equation

HRID 1447028 reaction equation
[ClH:1].[CH2:2]([N:9]1[CH:13]=[CH:12][N:11]=[C:10]1[CH2:14][CH:15]1[O:20][C:19]2[CH:21]=[CH:22][CH:23]=[CH:24][C:18]=2[O:17][CH2:16]1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.C(OCC)C>CO>[ClH:1].[CH2:2]([N:9]1[CH:13]=[CH:12][N:11]=[C:10]1[CH2:14][CH:15]1[O:20][C:19]2[CH:21]=[CH:22][CH:23]=[CH:24][C:18]=2[O:17][CH2:16]1)[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 127617712-[(2,3-Dihydro-1,4-benzodioxin-2-yl)methyl]-1-(phenylmethyl)-1H-imidazole

Product 1

HCID 12761772HCID 12761772, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

Excess 3% hydrogen chloride in methanol is added to a solution of 1.0 g 1-benzyl-2-(1,4-benzodioxan-2-ylmethyl)imidazole in 20 ml methanol. Diethyl ether is added until precipitation is complete. The product is filtered, washed with ether, air dried and recrystallized from methanol/acetone to yield 1-benzyl-2-(1,4-benzodioxan-2-ylmethyl)imidazole hydrochloride, m.p. 105°-107° C.(d).

Workup

  1. filtrationThe product is filtered
  2. washwashed with ether, air
  3. customdried
  4. customrecrystallized from methanol/acetone

Sources & evidence

ORD record
ord-6504e158555346cca1b426f81d6d0f2a
Source dataset
uspto-grants-1982_02
Patent number
US04315021

Reaction notes

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