Potassium Carbonate → 2-[(2,3-Dihydro-1,4-benzodioxin-2-yl)methyl]-1-(phenylmethyl)-1H-imidazole

HRID 1447029Notes

Reaction equation

HRID 1447029 reaction equation
Cl.[CH2:2]([N:9]1[CH:13]=[CH:12][N:11]=[C:10]1[CH2:14][CH:15]1[O:20][C:19]2[CH:21]=[CH:22][CH:23]=[CH:24][C:18]=2[O:17][CH2:16]1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.C(=O)([O-])[O-].[K+].[K+]>CCOCC>[CH2:2]([N:9]1[CH:13]=[CH:12][N:11]=[C:10]1[CH2:14][CH:15]1[O:20][C:19]2[CH:21]=[CH:22][CH:23]=[CH:24][C:18]=2[O:17][CH2:16]1)[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 12761772HCID 12761772, compound

Product 1

HCID 127617712-[(2,3-Dihydro-1,4-benzodioxin-2-yl)methyl]-1-(phenylmethyl)-1H-imidazole

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

1-Benzyl-2-(1,4-benzodioxan-2-ylmethyl)imidazole hydrochloride (1.0 g) suspended in 50 ml of ether is stirred with excess dilute aqueous potassium carbonate solution until the salt is completely dissolved. The organic layer is then separated, washed twice with water, dried over magnesium sulfate and evaporated to yield 1-benzyl-2-(1,4-benzodioxan-2-ylmethyl)imidazole.

Workup

  1. dissolutionis completely dissolved
  2. customThe organic layer is then separated
  3. washwashed twice with water
  4. dry with materialdried over magnesium sulfate
  5. customevaporated

Sources & evidence

ORD record
ord-98be6c1b3304495fa9b0c0fe1730be3a
Source dataset
uspto-grants-1982_02
Patent number
US04315021

Reaction notes

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