Thiocarbohydrazide → HCID 178441961, compound

HRID 1447057Notes

Reaction equation

HRID 1447057 reaction equation
C(N[C:5](=[O:12])[C:6]([C:8]([CH3:11])([CH3:10])[CH3:9])=O)(=O)C.[NH2:13][NH:14][C:15]([NH:17][NH2:18])=[S:16]>C(O)C.Cl>[NH2:13][N:14]1[C:5](=[O:12])[C:6]([C:8]([CH3:11])([CH3:10])[CH3:9])=[N:18][N:17]=[C:15]1[SH:16]

Participants

5

Reactant 2

HCID 2724189ThiocarbohydrazideHCID 12769196trimethylpyruvic acid N-acetylamide

Product 1

HCID 178441961HCID 178441961, compoundYield 95%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 702EthanolSolvent

Procedure

37.0 g (0.22 mol) of trimethylpyruvic acid N-acetylamide in 150 ml of ethanol were added dropwise to 23.2 g (0.22 mol) of thiocarbohydrazide in 400 ml of 1N HCl and the reaction mixture was subsequently stirred at room temperature for 5 hours. The product which had precipitated was filtered off, washed with water and dried. 41.2 g of the abovementioned product (VI) of melting point 210° C. were obtained, with a content, determined by gas chromatography, of >99% which corresponded to a yield of 95% of theory.

Workup

  1. customThe product which had precipitated
  2. filtrationwas filtered off
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-70c1d702552a4997b2fd66392018e797
Source dataset
uspto-grants-1982_02
Patent number
US04315094

Reaction notes

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