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HRID1447090

反应详情

EQUATION

反应方程式

HRID 1447090 的结构方程式

REACTANTS

反应物

2
结构：c1ccc(-c2ccccc2)cc1.c1ccc(Oc2ccccc2)cc1
HCID24670

Phenyl ether-biphenyl mixture

C24H20O

结构：C[C@]12CCC(=O)C=C1CC[C@H]1[C@@H]3CCC(=O)[C@@]3(C)C[C@H](O)[C@@]12Br
HCID11132685

未命名化合物

PRODUCTS

生成物

1
结构：C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2C(=O)C[C@]2(C)C(=O)CC[C@@H]12
HCID223997

未命名化合物

收率 80.6%

PROCEDURE

实验过程

Under argon gas, 1 g of 9α-bromo-11β-hydroxy-4-androstene-3,17-dione is agitated in 5 ml of "Dowtherm" A for 3 minutes at 250° C. To work up the reaction mixture, the solvent is removed by steam distillation, the residue is dried and recrystallized from methylene chloride-isopropyl ether, thus obtaining 635 mg of 4-androstene-3,11,17-trione, mp 214°-216° C.

WORKUP

后处理

  1. customthe solvent is removed by steam distillation
  2. customthe residue is dried
  3. customrecrystallized from methylene chloride-isopropyl ether