Ammonia → HCID 13055168, compound

HRID 1447126Notes

Reaction equation

HRID 1447126 reaction equation
Br[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][C:10]=1[C:11]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=O.[NH3:24]>O1CCCC1>[Cl:23][C:20]1[CH:21]=[CH:22][C:9]2[C:4]3[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=3[CH2:2][N:24]=[C:11]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[C:10]=2[CH:19]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 20468879HCID 20468879, compound

Product 1

HCID 13055168HCID 13055168, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The solution of 2.8 g of 2-(o-bromomethylphenyl)-5-chlorobenzophenone in 20 ml of tetrahydrofuran is added dropwise to the solution of 130 ml of saturated ethanolic ammonia while stirring. After 2 days' standing at room temperature the mixture is evaporated, the residue taken up in methylene chloride, the solution washed with aqueous sodium carbonate, dried, evaporated and the residue crystallized from methanol to give the 9-chloro-7-phenyl-5H-dibenz[c,e]azepine melting at 118°-119°.

Workup

  1. customthe mixture is evaporated
  2. washthe solution washed with aqueous sodium carbonate
  3. customdried
  4. customevaporated
  5. customthe residue crystallized from methanol

Sources & evidence

ORD record
ord-4d576d7f3749488ab3f0c3ca294df8bd
Source dataset
uspto-grants-1982_02
Patent number
US04315926

Reaction notes

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