Sodium → HCID 54738733, compound

HRID 1447134Notes

Reaction equation

HRID 1447134 reaction equation
[Na].C[O:3][C:4](=O)/[C:5](/[CH3:14])=[C:6](\[NH:8][CH2:9][C:10]([O:12][CH3:13])=[O:11])/[CH3:7]>CO>[CH3:13][O:12][C:10]([C:9]1[NH:8][C:6]([CH3:7])=[C:5]([CH3:14])[C:4]=1[OH:3])=[O:11]

Participants

4

Reactant 2

HCID 5360545SodiumHCID 12895159HCID 12895159, compound

Product 1

HCID 54738733HCID 54738733, compoundYield 83.6%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

Using the method described in Example 1, 5.7 g of sodium in 250 ml of methanol, and 40 g of 3-(methoxycarbonylmethylamino)-2-methylcrotonic acid methyl ester in 90 ml of methanol, give 28.1 g of 3-hydroxy-4,5-dimethyl-pyrrole-2-carboxylic acid methyl ester, of melting point 170°-172° C.

Sources & evidence

ORD record
ord-cb19c440c6464e8a9419b12ee12f1780
Source dataset
uspto-grants-1982_02
Patent number
US04315939

Reaction notes

Loading…