1-Bromo-2-Chloroethane → HCID 12895168, compound

HRID 1447139Notes

Reaction equation

[CH2:1]([O:3][C:4]([C:6]1[NH:7][C:8]([CH3:13])=[C:9]([CH3:12])[C:10]=1[OH:11])=[O:5])[CH3:2].[CH2:14]([Cl:17])[CH2:15]Br.C(=O)([O-])[O-].[K+].[K+]>>[C:4]([C:6]1[NH:7][C:8]([CH3:13])=[C:9]([CH3:12])[C:10]=1[O:11][CH2:15][CH2:14][Cl:17])([O:3][CH2:1][CH3:2])=[O:5]

Participants

Reactant 3

HCID 78491-Bromo-2-Chloroethane

HCID 11430Potassium Carbonate

HCID 54680365Ethyl 3-hydroxy-4,5-dimethyl-1H-pyrrole-2-carboxylate

Product 1

HCID 12895168HCID 12895168, compoundYield 40.7%

Procedure

Using the method described in Example X, 18.3 g of 3-hydroxy-4,5-dimethyl-pyrrole-2-carboxylic acid ethyl ester, 20.5 g of 1,2-bromochloroethane and 18 g of anhydrous potassium carbonate give 10 g of 1-(2-carboethoxy-4,5-dimethyl-pyrrol-3-oxy)-2-chloroethane, of melting point 81°-83° C.

Sources & evidence

ORD record: ord-108841efcbb54c14ae4d08e11388f7bd
Source dataset: uspto-grants-1982_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04315939

Reaction notes

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