反应详情

A mixture of 11.6 g (50 mmol) of 2-(4-aminophenyl)-4-hydroxy-5-pyrimidine carboxylic acid, 200 ml glacial acetic acid, and 10.5 ml (110 mmol) of acetic anhydride is heated at reflux for 4 hrs. The mixture is cooled, filtered, and the solid washed with ether and dried under vacuum at 50° to give 13.3 g of 2-[4-(acetylamino)phenyl]-4-hydroxy-5-pyrimidine carboxylic acid; mp>310°.

1. temperatureis heated
2. temperatureat reflux for 4 hrs
3. temperatureThe mixture is cooled
4. filtrationfiltered
5. washthe solid washed with ether
6. customdried under vacuum at 50°