Acetic Anhydride → HCID 178474101, compound

Participants

Reaction Steps

A mixture of 11.6 g (50 mmol) of 2-(4-aminophenyl)-4-hydroxy-5-pyrimidine carboxylic acid, 200 ml glacial acetic acid, and 10.5 ml (110 mmol) of acetic anhydride is heated at reflux for 4 hrs. The mixture is cooled, filtered, and the solid washed with ether and dried under vacuum at 50° to give 13.3 g of 2-[4-(acetylamino)phenyl]-4-hydroxy-5-pyrimidine carboxylic acid; mp>310°.

Provenance & Evidence