1,1-Dimethyl-2-thiourea → HCID 20551598, compound

HRID 1447191Notes

Reaction equation

HRID 1447191 reaction equation
Cl[CH2:2][C:3]([C:5]1[CH:10]=[C:9]([CH3:11])[CH:8]=[CH:7][C:6]=1[OH:12])=O.[CH3:13][N:14]([CH3:18])[C:15]([NH2:17])=[S:16]>>[CH3:13][N:14]([CH3:18])[C:15]1[S:16][CH:2]=[C:3]([C:5]2[CH:10]=[C:9]([CH3:11])[CH:8]=[CH:7][C:6]=2[OH:12])[N:17]=1

Participants

3

Reactant 2

HCID 30341921,1-Dimethyl-2-thioureaHCID 40129322-chloro-1-(2-hydroxy-5-methylphenyl)ethanone

Product 1

HCID 20551598HCID 20551598, compoundYield 96%

Procedure

17.5 g or 2-chloroacetyl-4-methylphenol and 10.9 g of N,N-dimethyl thiourea are heated for 20 minutes to 110° C. After cooling, the solidified mass is recrystallised from aqueous methanol, affording 14.2 g (96% of theory) of 2-dimethylamino-4-(2'-hydroxy-5'-methylphenyl)-thiazole of the formula (101) ##STR13## with a melting point of 108°-110° C.

Workup

  1. temperatureAfter cooling
  2. customthe solidified mass is recrystallised from aqueous methanol

Sources & evidence

ORD record
ord-3e49de8fbcf842fea08783f43e9575ff
Source dataset
uspto-grants-1982_02
Patent number
US04316036

Reaction notes

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