HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,1-Dimethyl-2-thiourea → HCID 20551598, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,1-Dimethyl-2-thiourea | HCID 3034192 | — |
| Reactant | 2-chloro-1-(2-hydroxy-5-methylphenyl)ethanone | HCID 4012932 | — |
| Product | HCID 20551598 | HCID 20551598 | 96% |
Reaction Steps
17.5 g or 2-chloroacetyl-4-methylphenol and 10.9 g of N,N-dimethyl thiourea are heated for 20 minutes to 110° C. After cooling, the solidified mass is recrystallised from aqueous methanol, affording 14.2 g (96% of theory) of 2-dimethylamino-4-(2'-hydroxy-5'-methylphenyl)-thiazole of the formula (101) ##STR13## with a melting point of 108°-110° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04316036 |
| Source dataset | uspto-grants-1982_02 |
| ORD ID | ord-3e49de8fbcf842fea08783f43e9575ff |
| Source note | uspto-grants-1982_02 |