HCID 13205870, compound → HCID 13205871, compound

HRID 1447202Notes

Reaction equation

HRID 1447202 reaction equation
[CH:1]([N:4]([CH:9]1[CH:23]=[C:22]([CH3:24])[CH2:21][CH:20]=[C:10]1[C:11]([C:13]1[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=1)=[O:12])[C:5]([O:7][CH3:8])=[O:6])([CH3:3])[CH3:2]>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[CH:1]([N:4]([C:9]1[CH:23]=[C:22]([CH3:24])[CH:21]=[CH:20][C:10]=1[C:11]([C:13]1[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=1)=[O:12])[C:5]([O:7][CH3:8])=[O:6])([CH3:3])[CH3:2]

Participants

4

Reactant 1

HCID 13205870HCID 13205870, compound

Product 1

HCID 13205871HCID 13205871, compound

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 6212ChloroformSolvent

Procedure

20 g 2-(N-isopropyl-N-carbomethoxyamino)-4-methyl-4'-fluoro-2,5-dihydrobenzophenone and 100 g manganese dioxide in 200 ml chloroform are stirred 4 hours under reflux. The reaction mixture is cooled, filtered and evaporated in vacuo. The residue is recrystallised from hexane to obtain the heading compound, m.p. 92°-94° C.

Workup

  1. temperatureunder reflux
  2. temperatureThe reaction mixture is cooled
  3. filtrationfiltered
  4. customevaporated in vacuo
  5. customThe residue is recrystallised from hexane
  6. customto obtain the heading compound, m.p. 92°-94° C.

Sources & evidence

ORD record
ord-829053cd9ef64de6941a40012ebb61a0
Source dataset
uspto-grants-1982_02
Patent number
US04316042

Reaction notes

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