反应详情

Using the method for the preparation of the side chain acid in Example 3, 11.5 g (50 mmol) of 6-(4-aminophenyl)-1,2-dihydro-2-oxonicotinic acid, 500 ml of dichloromethane, 21.0 ml (150 mmol) of triethylamine, 20 ml (158 mmol) of chlorotrimethylsilane, and 5.67 g (55 mmol) of cyanoacetyl chloride [Org. Syn. Col. Vol. V p. 171] gives 14.7 g of 6-[4-(cyanoacetylamino)phenyl]-1,2-dihydro-2-oxonicotinic acid; mp>280°.