HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1447297Generated: October 26, 2026
Formaldehyde → 1-Phenyl-4-(beta-morpholinopropionyl)-pyrazole hydrochloride
https://huagongshe.com/reaction/1447297
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Glycol monoethyl ether | HCID 8076 | — |
| Reactant | Morpholine, hydrochloride (1:1) | HCID 197884 | — |
| Reactant | 1-(1-phenyl-1H-pyrazol-4-yl)ethan-1-one | HCID 822987 | — |
| Product | 1-Phenyl-4-(beta-morpholinopropionyl)-pyrazole hydrochloride | HCID 20550538 | — |
Reaction Steps
1-Phenyl-4-acetyl pyrazole (17.9 g) was mixed with paraformaldehyde (3.2 g), morpholine hydrochloride (11.71 g) and cellosolve (37 ml). The mixture was refluxed for 30 minutes and then cooled to 5° C. The white coloured Mannich Base was filted and washed with ethyl alcohol (100 ml) and acetone (50 ml). The white solid was dried at 70° C. to give 1-phenyl-4-(β-morpholinopropionyl)-pyrazole hydrochloride ##STR33## m.p. 212°-214° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04316815 |
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| Source dataset | uspto-grants-1982_02 |
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| ORD ID | ord-dbf2e04fa6a14316901c5a9c2a043f8e |
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| Source note | uspto-grants-1982_02 |
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