反应详情

温度

5 °C

1-Phenyl-4-acetyl pyrazole (17.9 g) was mixed with paraformaldehyde (3.2 g), morpholine hydrochloride (11.71 g) and cellosolve (37 ml). The mixture was refluxed for 30 minutes and then cooled to 5° C. The white coloured Mannich Base was filted and washed with ethyl alcohol (100 ml) and acetone (50 ml). The white solid was dried at 70° C. to give 1-phenyl-4-(β-morpholinopropionyl)-pyrazole hydrochloride ##STR33## m.p. 212°-214° C.

1. temperatureThe mixture was refluxed for 30 minutes
2. washwashed with ethyl alcohol (100 ml) and acetone (50 ml)
3. customThe white solid was dried at 70° C.