Tetrahydrofuran → 7-bromo-3-chloro-1-fluoro-5-(2-hydroxyethyl)-5H-chromeno[2,3-c]pyridin-5-ol
Reaction equation
[Br:1][c:2]1[cH:3][c:4]2[c:15]([cH:16][cH:17]1)[O:14][c:7]1[c:6]([cH:11][c:10]([Cl:12])[n:9][c:8]1[F:13])[C:5]2([OH:18])[CH2:19][C:20](=[O:21])[O:22][C:23]([CH3:24])([CH3:25])[CH3:26].[CH2:28]([Al+:29][CH2:30][CH:31]([CH3:32])[CH3:33])[CH:34]([CH3:35])[CH3:36].[CH2:37]1[O:38][CH2:39][CH2:40][CH2:41]1.[H-:27]>>[Br:1][c:2]1[cH:3][c:4]2[c:15]([cH:16][cH:17]1)[O:14][c:7]1[c:6]([cH:11][c:10]([Cl:12])[n:9][c:8]1[F:13])[C:5]2([OH:18])[CH2:19][CH2:20][OH:21]Participants
5
Sources & evidence
- ORD record
- ord-d093d6f9013643a1912f12a77b8d797d
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaction notes
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