Methyl Acrylate → HCID 54015973, compound

HRID 1447411Notes

Reaction equation

HRID 1447411 reaction equation
[CH3:1][NH:2][CH2:3][CH:4]1[C:10]2=[CH:11][CH:12]=[CH:13][N:9]2[CH2:8][C:7]2[CH:14]=[CH:15][CH:16]=[CH:17][C:6]=2[NH:5]1.[C:18]([O:22][CH3:23])(=[O:21])[CH:19]=[CH2:20]>>[CH3:1][N:2]([CH2:3][CH:4]1[C:10]2=[CH:11][CH:12]=[CH:13][N:9]2[CH2:8][C:7]2[CH:14]=[CH:15][CH:16]=[CH:17][C:6]=2[NH:5]1)[CH2:20][CH2:19][C:18]([O:22][CH3:23])=[O:21]

Participants

3

Reactant 2

HCID 7294Methyl AcrylateHCID 13163311HCID 13163311, compound

Product 1

HCID 54015973HCID 54015973, compound

Procedure

The starting material is prepared as follows: The solution of 1.5 g of 11-(N-methylaminomethyl)-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine (Example 1) in 7.5 ml of methyl acrylate is stirred at room temperature for 24 hours and the excess reagent is evaporated to yield the 11-(N-methyl-N-methoxycarbonylethylamino-methyl)-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine as an oil, which is chromatographed on silica gel and eluted with 2% methanol-methylene chloride.

Workup

  1. customThe starting material is prepared
  2. customthe excess reagent is evaporated

Sources & evidence

ORD record
ord-7294ce2389514f2784910044447744dc
Source dataset
uspto-grants-1982_02
Patent number
US04316900

Reaction notes

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