Hydrogen Bromide → HCID 20550939, compound

HRID 1447419Notes

Reaction equation

HRID 1447419 reaction equation
[C:1]([C:4]1[S:8][CH:7]=[C:6]([C:9]([NH2:11])=[O:10])[CH:5]=1)(=[O:3])[CH3:2].[BrH:12].BrBr>C(Cl)(Cl)Cl.C(O)(=O)C>[Br:12][CH2:2][C:1]([C:4]1[S:8][CH:7]=[C:6]([C:9]([NH2:11])=[O:10])[CH:5]=1)=[O:3]

Participants

6

Reactant 3

HCID 260Hydrogen BromideHCID 24408BromineHCID 205509375-Acetylthiophene-3-carboxamide

Product 1

HCID 20550939HCID 20550939, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidCatalystHCID 6212ChloroformSolvent2×

Procedure

A solution of 5-acetylthiophene-3-carboxamide (0.5 g) in chloroform at 50° was treated with hydrogen bromide in acetic acid (4 drops) and then bromine (0.15 ml) in chloroform (10 ml) dropwise over 30 min. The resulting pale yellow solution was washed with water (2×100 ml), dried and evaporated to small volume to deposit the title compound as a white solid (0.55 g) which recrystallised from water, m.p. 150°-157° (d).

Workup

  1. washThe resulting pale yellow solution was washed with water (2×100 ml)
  2. customdried
  3. customevaporated to small volume
  4. customrecrystallised from water, m.p. 150°-157° (d)

Sources & evidence

ORD record
ord-e37ce2377dc84078a3014aa9c3f5b49e
Source dataset
uspto-grants-1982_02
Patent number
US04316907

Reaction notes

Loading…