Methanesulfonyl chloride → HCID 10878028, compound

HRID 1447429Notes

Reaction equation

HRID 1447429 reaction equation
[CH3:1][C:2]([CH3:8])([CH2:6][OH:7])[C:3](=[O:5])[CH3:4].[CH3:9][S:10](Cl)(=[O:12])=[O:11]>N1C=CC=CC=1.C(Cl)Cl>[CH3:9][S:10]([O:7][CH2:6][C:2]([CH3:8])([CH3:1])[C:3](=[O:5])[CH3:4])(=[O:12])=[O:11]

Participants

5

Reactant 2

HCID 31297Methanesulfonyl chlorideHCID 111943184-Hydroxy-3,3-dimethylbutan-2-one

Product 1

HCID 10878028HCID 10878028, compoundYield 86%

Reagents, catalysts & solvents 2

HCID 1049PyridineSolventHCID 6344DichloromethaneSolvent

Procedure

232 g (2 mols) of 3,3-dimethyl-4-hydroxy-2-butanone (for the preparation, see Beilstein H 1 E III 3,239, IV 4,030 and Bull. Soc. Chim. France 1964, 2,849) were reacted with 229 g (2 mols) of methanesulphonyl chloride in 700 ml of absolute pyridine at 0° to 5° C. After leaving the mixture to stand at 20° C. for 12 hours, it was diluted with methylene chloride and extracted by shaking with icewater. The organic phase was dried and freed from solvent in vacuo and the residue was fractionated over a column. 332 g (86% of theory) of 2,2-dimethyl-3-oxo-butyl methane-sulphonate of boiling point 106°-120° C./0.12 mm Hg were obtained. ##STR27##

Workup

  1. customAfter leaving the mixture
  2. extractionextracted
  3. customThe organic phase was dried

Sources & evidence

ORD record
ord-c561b8947359475fbb81bd04a4c16505
Source dataset
uspto-grants-1982_02
Patent number
US04316910

Reaction notes

Loading…