Methanesulfonyl chloride → HCID 10878028, compound

Participants

Reaction Steps

232 g (2 mols) of 3,3-dimethyl-4-hydroxy-2-butanone (for the preparation, see Beilstein H 1 E III 3,239, IV 4,030 and Bull. Soc. Chim. France 1964, 2,849) were reacted with 229 g (2 mols) of methanesulphonyl chloride in 700 ml of absolute pyridine at 0° to 5° C. After leaving the mixture to stand at 20° C. for 12 hours, it was diluted with methylene chloride and extracted by shaking with icewater. The organic phase was dried and freed from solvent in vacuo and the residue was fractionated over a column. 332 g (86% of theory) of 2,2-dimethyl-3-oxo-butyl methane-sulphonate of boiling point 106°-120° C./0.12 mm Hg were obtained. ##STR27##

Provenance & Evidence