Pyridine → HCID 70609554, compound

HRID 1447538Notes

Reaction equation

HRID 1447538 reaction equation
Br[CH2:2][CH2:3][CH2:4][CH:5]1[O:17][CH2:16][CH2:15][O:14][CH:6]1[CH2:7][CH:8]1[O:13][CH2:12][CH2:11][O:10][CH2:9]1.[I-:18].[K+].N1C=CC=CC=1.CCOCC>CC(=O)CC>[I:18][CH2:2][CH2:3][CH2:4][CH:5]1[O:17][CH2:16][CH2:15][O:14][CH:6]1[CH2:7][CH:8]1[O:13][CH2:12][CH2:11][O:10][CH2:9]1

Participants

6

Reactant 4

HCID 1049PyridineHCID 3283Diethyl EtherHCID 4875Potassium IodideHCID 70609867HCID 70609867, compound

Product 1

HCID 70609554HCID 70609554, compoundYield 95.9%

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

The bromide from Example XIX (7.5 g, 0.024 mol) was dissolved in butan-2-one (70 ml), after which powdered potassium iodide (6.8 g, 0.04 mol) and pyridine (0.2 ml) were added. The mixture was refluxed for 11/2 hours, mixed with ether, and filtered. Evaporation yielded 8.2 g product (95% by weight yield).

Workup

  1. temperatureThe mixture was refluxed for 11/2 hours
  2. filtrationfiltered
  3. customEvaporation

Sources & evidence

ORD record
ord-f7a582e15ccb40bd9c45a932165446f4
Source dataset
uspto-grants-1979_12
Patent number
US04177197

Reaction notes

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