HCID 12608491, compound → N-{1-[2-(1H-Indol-3-yl)ethyl]piperidin-4-yl}urea

HRID 1447588Notes

Reaction equation

HRID 1447588 reaction equation
Cl.C([NH:10][C:11]([NH:13][CH:14]1[CH2:19][CH2:18][N:17]([CH2:20][CH2:21][C:22]2[C:30]3[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=3)[NH:24][CH:23]=2)[CH2:16][CH2:15]1)=[O:12])(=O)C1C=CC=CC=1>[OH-].[Na+]>[NH:24]1[C:25]2[C:30](=[CH:29][CH:28]=[CH:27][CH:26]=2)[C:22]([CH2:21][CH2:20][N:17]2[CH2:16][CH2:15][CH:14]([NH:13][C:11]([NH2:10])=[O:12])[CH2:19][CH2:18]2)=[CH:23]1

Participants

3

Reactant 1

HCID 12608491HCID 12608491, compound

Product 1

HCID 12608470N-{1-[2-(1H-Indol-3-yl)ethyl]piperidin-4-yl}urea

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

1-benzoyl-3-[1-(2-[3-indolyl]ethyl)piperid-4-yl]urea hydrochloride (1.180 g.) was refluxed in 2 N sodium hydroxide solution (20 ml) for 1 hour. The reaction mixture was cooled and the title compound was filtered off, (0.678 g., 86%) m.p. 212.2° (dec).

Workup

  1. temperatureThe reaction mixture was cooled
  2. filtrationthe title compound was filtered off

Sources & evidence

ORD record
ord-62dc37ddb1b84f608295df429d67b065
Source dataset
uspto-grants-1979_12
Patent number
US04177279

Reaction notes

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