Cyclohexyl isocyanate → HCID 12608488, compound

HRID 1447592Notes

Reaction equation

HRID 1447592 reaction equation
O.[NH2:2][CH:3]1[CH2:8][CH2:7][N:6]([CH2:9][CH2:10][C:11]2[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[NH:13][CH:12]=2)[CH2:5][CH2:4]1.[CH:20]1([N:26]=[C:27]=[O:28])[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]1>C1C=CC=CC=1>[NH:13]1[C:14]2[C:19](=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:11]([CH2:10][CH2:9][N:6]2[CH2:7][CH2:8][CH:3]([NH:2][C:27]([NH:26][CH:20]3[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]3)=[O:28])[CH2:4][CH2:5]2)=[CH:12]1

Participants

4

Reactant 2

HCID 18502Cyclohexyl isocyanateHCID 203843533-[2-(4-Aminopiperidyl)ethyl]indole, hydrate

Product 1

HCID 12608488HCID 12608488, compoundYield 102.7%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

4-Amino-1-[2-(3-indolyl)ethyl]piperidine, hydrate (1.307 g, 0.005 mole) in benzene (50 ml.) was treated with cyclohexyl isocyanate (0.688 g, 0.0055 mole) and the mixture stirred for 18 hrs. Filtration afforded the title compound as colourless prisms (1.893 g), m.p. 203.8°.

Workup

  1. filtrationFiltration

Sources & evidence

ORD record
ord-ecd7cce690254d44bf65acacb1f8d43b
Source dataset
uspto-grants-1979_12
Patent number
US04177279

Reaction notes

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