Phenyl Isothiocyanate → HCID 12608502, compound

HRID 1447593Notes

Reaction equation

HRID 1447593 reaction equation
[CH3:1][NH:2][CH:3]1[CH2:8][CH2:7][N:6]([CH2:9][CH2:10][C:11]2[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[NH:13][CH:12]=2)[CH2:5][CH2:4]1.[C:20]1([N:26]=[C:27]=[S:28])[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>C1C=CC=CC=1>[NH:13]1[C:14]2[C:19](=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:11]([CH2:10][CH2:9][N:6]2[CH2:5][CH2:4][CH:3]([N:2]([CH3:1])[C:27]([NH:26][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[S:28])[CH2:8][CH2:7]2)=[CH:12]1

Participants

4

Reactant 2

HCID 7673Phenyl IsothiocyanateHCID 12608469HCID 12608469, compound

Product 1

HCID 12608502HCID 12608502, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

3-[2-(4-Methylaminopiperidyl)ethyl]indole (1.28 g, 0.005 mole) was stirred in dry benzene (75 ml) and treated with phenyl isothiocyanate (0.74 g, 0.0055 mole). Stirring was continued for 24 hr. and the mixture evaporated to give the title compound, which was converted to the hydrochloride by addition of hydrogen chloride in ethanol and precipitation with ether. Yield, 0.95 g, m.p. 193.7°.

Workup

  1. customand the mixture evaporated

Sources & evidence

ORD record
ord-ed6429507415461fb6ce08f497132398
Source dataset
uspto-grants-1979_12
Patent number
US04177279

Reaction notes

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