Sodium Hydroxide → HCID 12608569, compound

HRID 1447595Notes

Reaction equation

HRID 1447595 reaction equation
C([NH:9][C:10]([NH:12][CH:13]1[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C:21]2[C:29]3[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=3)[NH:23][CH:22]=2)[CH2:15][CH2:14]1)=[S:11])(=O)C1C=CC=CC=1.[OH-].[Na+]>O>[NH:23]1[C:24]2[C:29](=[CH:28][CH:27]=[CH:26][CH:25]=2)[C:21]([CH2:20][CH2:19][N:16]2[CH2:15][CH2:14][CH:13]([NH:12][C:10]([NH2:9])=[S:11])[CH2:18][CH2:17]2)=[CH:22]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 12608504HCID 12608504, compound

Product 1

HCID 12608569HCID 12608569, compoundYield 96.7%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

1-Benzoyl-3-[1-(2-[3-indolyl]ethyl)piperid-4-yl]-thiourea (2.21 g) was refluxed in water (20 ml) containing sodium hydroxide (1.0 g) for 5 min. The mixture was cooled and filtered to afford the title compound (1.59 g). Crystallisation from EtOH-HCl/ether afforded the hydrochloride (1.467 g), m.p. 228°-9°.

Workup

  1. temperatureThe mixture was cooled
  2. filtrationfiltered

Sources & evidence

ORD record
ord-76af09f6ac58493ab120296dda28fe5c
Source dataset
uspto-grants-1979_12
Patent number
US04177279

Reaction notes

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