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HRID1447699

反应详情

EQUATION

反应方程式

HRID 1447699 的结构方程式

REACTANTS

反应物

3
结构：Cl
HCID313

Hydrochloric Acid

ClH

结构：CCO
HCID702

Ethanol

C2H6O

结构：CC1(c2ccc(CNC(=O)CCl)cc2)Cc2cc(OCC(=O)O)c(Cl)c(Cl)c2C1=O
HCID12423624

未命名化合物

PRODUCTS

生成物

1
结构：CCOC(=O)COc1cc2c(c(Cl)c1Cl)C(=O)C(C)(c1ccc(CN)cc1)C2.Cl
HCID20378231

未命名化合物

CONDITIONS

反应条件

温度
5 °C

PROCEDURE

实验过程

{1-Oxo-2-[4-(2-chloroacetamidomethyl)phenyl]-2-methyl-6,7-dichloro-5-indanyloxy}acetic acid (2.0 g., 0.004 mole), absolute ethanol (20 ml.) and 12 N hydrochloric acid (7 ml.) are combined and heated at reflux for 3 hours. On cooling to 5° C. 1.14 g. of ethyl[1-oxo-2-(4-aminomethylphenyl)-2-methyl-6,7-dichloro-5-indanyloxy]acetate hydrochloride precipitates and melts at 211°-213° C. after crystallization from ethanol.

WORKUP

后处理

  1. temperatureheated
  2. temperatureat reflux for 3 hours
  3. customof ethyl[1-oxo-2-(4-aminomethylphenyl)-2-methyl-6,7-dichloro-5-indanyloxy]acetate hydrochloride precipitates
  4. custommelts at 211°-213° C. after crystallization from ethanol