Hydrochloric Acid → HCID 20344235, compound

HRID 1447733Notes

Reaction equation

HRID 1447733 reaction equation
[CH3:1][C:2]1[C:3](=[O:18])[C:4]2[CH2:13][S:12][C:11]3[CH:14]=[CH:15][CH:16]=[CH:17][C:10]=3[C:5]=2[O:6][C:7]=1C#N.Cl.[OH-:20].[Na+]>CO>[CH3:1][CH:2]1[C:7](=[O:20])[O:6][C:5]2[C:10]3[CH:17]=[CH:16][CH:15]=[CH:14][C:11]=3[S:12][CH2:13][C:4]=2[C:3]1=[O:18]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 12561496HCID 12561496, compound

Product 1

HCID 20344235HCID 20344235, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 3-methyl-4-oxo-4H,5H-[1]benzothiopyrano[4,3-b]pyran-2-carbonitrile (0.255 g, 1 mmole, described in Example 6) in 2.5N aqueous sodium hydroxide (10 ml) and methanol (5 ml) is refluxed overnight. The solution is acidified with hydrochloric acid. The precipitate is collected and dissolved in IN aqueous sodium hydroxide. The solution is washed with chloroform and acidified with hydrochloric acid. The precipitate is collected and crystallized from methanol to give the title compound (0.070 g), mp 275°-277° C.

Workup

  1. customThe precipitate is collected
  2. dissolutiondissolved in IN aqueous sodium hydroxide
  3. washThe solution is washed with chloroform
  4. customThe precipitate is collected
  5. customcrystallized from methanol

Sources & evidence

ORD record
ord-e35338a480ec4cc59f48b87987452372
Source dataset
uspto-grants-1979_12
Patent number
US04177284

Reaction notes

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