Sodium Bicarbonate → Propyl N-((5-methyl-2-(isopropyl)cyclohexyl)carbonyl)glycinate

HRID 1447840Notes

Reaction equation

HRID 1447840 reaction equation
[CH:1]1([CH3:13])[CH2:6][CH2:5][CH:4]([CH:7]([CH3:9])[CH3:8])[CH:3]([C:10](Cl)=[O:11])[CH2:2]1.Cl.[CH2:15]([O:18][C:19](=[O:22])[CH2:20][NH2:21])[CH2:16][CH3:17].C(=O)(O)[O-].[Na+]>>[CH2:15]([O:18][C:19](=[O:22])[CH2:20][NH:21][C:10]([CH:3]1[CH:4]([CH:7]([CH3:9])[CH3:8])[CH2:5][CH2:6][CH:1]([CH3:13])[CH2:2]1)=[O:11])[CH2:16][CH3:17]

Participants

4

Reactant 3

HCID 516892Sodium BicarbonateHCID 2759254Propyl aminoacetate hydrochlorideHCID 13734319Cyclohexanecarbonyl chloride, 5-methyl-2-(1-methylethyl)-

Product 1

HCID 56843152Propyl N-((5-methyl-2-(isopropyl)cyclohexyl)carbonyl)glycinate

Procedure

Following the procedure of Example 2 p-menth-3-oyl chloride (2.0 g., 0.01 moles), was reacted with glycine propyl ester hydrochloride (1.5 g., 0.01 moles) and sodium bicarbonate (1.6 g., 0.02 moles). The crude product was distilled b.p. 170°/0.1 mm. (After distillation the product rapidly solidifies). (Found, C: 68.2; H: 1016; N: 5.0. C16H29NO3 requires, C: 67.8; H: 10.6; N: 4.9.)

Workup

  1. distillationThe crude product was distilled b.p. 170°/0.1 mm
  2. distillation(After distillation the product

Sources & evidence

ORD record
ord-984c0a0f5827447bb43187f79b90ce35
Source dataset
uspto-grants-1979_12
Patent number
US04178459

Reaction notes

Loading…