Hydrochloric Acid → 7-(alpha,alpha,alpha-Trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid

HRID 1447859Notes

Reaction equation

HRID 1447859 reaction equation
[Na+].[F:2][C:3]([F:23])([F:22])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]2[N:15]3[N:16]=[CH:17][C:18]([C:19]([O-:21])=[O:20])=[C:14]3[N:13]=[CH:12][CH:11]=2)[CH:5]=1.Cl>C(Cl)Cl>[F:22][C:3]([F:2])([F:23])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]2[N:15]3[N:16]=[CH:17][C:18]([C:19]([OH:21])=[O:20])=[C:14]3[N:13]=[CH:12][CH:11]=2)[CH:5]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 705907417-(alpha,alpha,alpha-Trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid sodium salt

Product 1

HCID 103353477-(alpha,alpha,alpha-Trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of 0.70 g. of 7-(α,α,α-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid sodium salt, 25 ml. of methylene chloride and 10 ml. of 1 N hydrochloric acid is stirred overnight. The solid which forms is collected by filtration. The filtrate is evaporated to produce more solid. The solids are combined and recrystallized from methylene chloride giving the desired product, m.p. 248°-250° C.

Workup

  1. additionA mixture of 0.70 g
  2. filtrationThe solid which forms is collected by filtration
  3. customThe filtrate is evaporated
  4. customto produce more solid
  5. customrecrystallized from methylene chloride giving the desired product, m.p. 248°-250° C.

Sources & evidence

ORD record
ord-b271db2ed96b4fb7b418664539371e6e
Source dataset
uspto-grants-1979_12
Patent number
US04178449

Reaction notes

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