Dimethylformamide dimethyl acetal → 3-Dimethylamino-2-methyl-3'-(trifluoromethyl)acrylophenone

HRID 1447863Notes

Reaction equation

HRID 1447863 reaction equation
[F:1][C:2]([F:14])([F:13])[C:3]1[CH:4]=[C:5]([C:9](=[O:12])[CH2:10][CH3:11])[CH:6]=[CH:7][CH:8]=1.CO[CH:17](OC)[N:18]([CH3:20])[CH3:19]>>[CH3:20][N:18]([CH3:19])[CH:17]=[C:10]([CH3:11])[C:9]([C:5]1[CH:6]=[CH:7][CH:8]=[C:3]([C:2]([F:1])([F:13])[F:14])[CH:4]=1)=[O:12]

Participants

3

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 137064Propiophenone, 3'-(trifluoromethyl)

Product 1

HCID 545299423-Dimethylamino-2-methyl-3'-(trifluoromethyl)acrylophenone

Procedure

A mixture of 25 g. of m-trifluoromethylpropiophenone and 25 ml. of dimethylformamide dimethylacetal is refluxed overnight and then evaporated to an oil. The oil is dissolved in hexane and the solution is refrigerated giving crystals of the desired product, m.p. 53°-55° C.

Workup

  1. additionA mixture of 25 g
  2. customevaporated to an oil
  3. dissolutionThe oil is dissolved in hexane

Sources & evidence

ORD record
ord-f3127b22e1ac4643be4bf18e9fe40f1d
Source dataset
uspto-grants-1979_12
Patent number
US04178449

Reaction notes

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