Dimethylformamide dimethyl acetal → 3-Dimethylamino-3'-methoxyacrylophenone

HRID 1447867Notes

Reaction equation

HRID 1447867 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:9](=[O:12])[CH:10]=[CH2:11])[CH:6]=[CH:7][CH:8]=1.CO[CH:15](OC)[N:16](C)[CH3:17]>>[CH3:15][N:16]([CH3:17])[CH:11]=[CH:10][C:9]([C:5]1[CH:6]=[CH:7][CH:8]=[C:3]([O:2][CH3:1])[CH:4]=1)=[O:12]

Participants

3

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 102613932-Propen-1-one, 1-(3-methoxyphenyl)-

Product 1

HCID 425737963-Dimethylamino-3'-methoxyacrylophenone

Procedure

A mixture of 25 g. of m-methoxyacrylophenone and 25 ml. of dimethylformamide dimethyl acetal is refluxed for 12 hours. Removal of any volatile material in vacuo gives a thick oil. Bulb to bulb distillation gives the desired product.

Workup

  1. additionA mixture of 25 g
  2. customRemoval of any volatile material in vacuo
  3. customgives a thick oil
  4. distillationBulb to bulb distillation

Sources & evidence

ORD record
ord-881ccfcdebc345638f5339fabc3b56bc
Source dataset
uspto-grants-1979_12
Patent number
US04178449

Reaction notes

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