反应详情

A mixture of 1.0 g. of 8-bromo-4-(α,α,α-trifluoro-m-tolyl)imidazo[1,5-a]pyrimidine, 0.45 g. of cuprous cyanide and 25 ml. of N,N-dimethylformamide is refluxed for 16 hours. The solvent is removed under reduced pressure. The residue is extracted with methylene chloride and the solution passed through a column of hydrous magnesium silicate. The eluent is collected, concentrated and n-hexane added while heating. The product separates as crystals, m.p. 168°-169° C.

1. additionA mixture of 1.0 g
2. customThe solvent is removed under reduced pressure
3. extractionThe residue is extracted with methylene chloride
4. customThe eluent is collected
5. concentrationconcentrated
6. additionn-hexane added
7. temperaturewhile heating