Hydrochloric Acid → 4-(Trifluoromethoxy)benzyl Chloride

HRID 1447918Notes

Reaction equation

HRID 1447918 reaction equation
O1CC[CH2:4]OO1.[F:7][C:8]([F:17])([F:16])[O:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.[ClH:18]>[Cl-].[Zn+2].[Cl-]>[F:7][C:8]([F:16])([F:17])[O:9][C:10]1[CH:15]=[CH:14][C:13]([CH2:4][Cl:18])=[CH:12][CH:11]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 68010(Trifluoromethoxy)benzeneHCID 19593658CID 19593658

Product 1

HCID 27772614-(Trifluoromethoxy)benzyl Chloride

Reagents, catalysts & solvents 1

HCID 3007855ZincchlorideCatalyst

Procedure

A mixture of trioxane (355 mg), zinc chloride (340 mg) and trifluoromethoxybenzene (600 mg) is heated at 73° C. while hydrogen chloride gas is bubbled through the reaction mixture. The reaction is cooled to room temperature and diluted with ether. The organic phase is washed with saturated sodium carbonate solution and water. Removal of the solvents gives the product as a colorless liquid (1.42 g).

Workup

  1. customis bubbled through the reaction mixture
  2. additiondiluted with ether
  3. washThe organic phase is washed with saturated sodium carbonate solution and water
  4. customRemoval of the solvents

Sources & evidence

ORD record
ord-e24855e8659a4fe1bb26bcb8a24d308c
Source dataset
uspto-grants-1979_12
Patent number
US04178460

Reaction notes

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