反应详情

The α-cyano-m-phenoxybenzyl esters of the above are prepared using the procedure of Example 10 by reacting, e.g. 1,2-bis(bromomethyl)-3-trifluoromethylbenzene with valine to prepare 2-(4-trifluoromethyl-2-isoindolinyl)-3-methylbutanoic acid and esterifying using α-cyano-m-phenoxybenzyl mesylate.