18000-76-5 → HCID 70601729, compound

HRID 1447972Notes

Reaction equation

HRID 1447972 reaction equation
[CH3:1][O:2][CH2:3][O:4][C@H:5]1[CH2:22][CH2:21][C@@:20]2([CH3:23])[C:7](=[CH:8][CH2:9][C@@H:10]3[C@@H:19]2[CH2:18][CH2:17][C@@:15]2([CH3:16])[C@H:11]3[CH2:12][CH2:13][C:14]2=[O:24])[CH2:6]1.COCO[C@H]1CC[C@@]2(C)[C@@H](CC[C@@H]3[C@@H]2CC[C@@]2(C)[C@H]3CCC2=O)C1>CO>[CH3:1][O:2][CH2:3][O:4][C@H:5]1[CH2:22][CH2:21][C@@:20]2([CH3:23])[C@@H:7]([CH2:8][CH2:9][C@@H:10]3[C@@H:19]2[CH2:18][CH2:17][C@@:15]2([CH3:16])[C@H:11]3[CH2:12][CH2:13][C@@H:14]2[OH:24])[CH2:6]1

Participants

4

Reactant 2

HCID 1083043318000-76-5HCID 10903773HCID 10903773, compound

Product 1

HCID 70601729HCID 70601729, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1.1 g. of 3β-methoxymethoxy-5-androsten-17-one is hydrogenated as disclosed in Example 25. The thus-obtained crude product is not quite uniform and contains, in addition to 3β-methoxymethoxy-5α-androstan-17-one, of which 0.65 g. can be obtained by crystallization from methanol, also proportions of 3β-methoxymethoxy-5α-androstan-17β-ol. By continuing the hydrogenation or by reduction with sodium borohydride, this product becomes the primary yield.

Workup

  1. customThe thus-obtained crude product

Sources & evidence

ORD record
ord-4721e52898924a49b3aed794cfc1aef4
Source dataset
uspto-grants-1979_12
Patent number
US04179336

Reaction notes

Loading…