Thionyl Chloride → HCID 20298835, compound

HRID 1448089Notes

Reaction equation

HRID 1448089 reaction equation
[CH3:1][C:2]1[N:6]([CH2:7][CH2:8][CH3:9])[C:5]2[CH:10]=[CH:11][C:12]([C:14]([OH:16])=O)=[CH:13][C:4]=2[N:3]=1.S(Cl)([Cl:19])=O>ClC(Cl)Cl>[ClH:19].[CH3:1][C:2]1[N:6]([CH2:7][CH2:8][CH3:9])[C:5]2[CH:10]=[CH:11][C:12]([C:14]([Cl:19])=[O:16])=[CH:13][C:4]=2[N:3]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 202988562-Methyl-1-propyl-1,3-benzodiazole-5-carboxylic acid

Product 1

HCID 20298835HCID 20298835, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

To a stirred mixture of 18 parts of 2-methyl-1-propyl-1H-benzimidazole-5-carboxylic acid and 150 parts of trichloromethane are added dropwise 29.8 parts of thionyl chloride. Upon completion, stirring is continued for 20 minutes at reflux. The reaction mixture is cooled, dried, filtered and evaporated, yielding 22.5 parts of 2-methyl-1-propyl-1H-benzimidazole-5-carbonyl chloride monohydrochloride as a residue.

Workup

  1. temperatureat reflux
  2. temperatureThe reaction mixture is cooled
  3. customdried
  4. filtrationfiltered
  5. customevaporated

Sources & evidence

ORD record
ord-a778eae569254d1cabce940752985c51
Source dataset
uspto-grants-1979_12
Patent number
US04179505

Reaction notes

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