反应详情

To a stirred mixture of 18 parts of 2-methyl-1-propyl-1H-benzimidazole-5-carboxylic acid and 150 parts of trichloromethane are added dropwise 29.8 parts of thionyl chloride. Upon completion, stirring is continued for 20 minutes at reflux. The reaction mixture is cooled, dried, filtered and evaporated, yielding 22.5 parts of 2-methyl-1-propyl-1H-benzimidazole-5-carbonyl chloride monohydrochloride as a residue.

1. temperatureat reflux
2. temperatureThe reaction mixture is cooled
3. customdried
4. filtrationfiltered
5. customevaporated