Dichloromethane → HCID 70606969, compound

HRID 1448135Notes

Reaction equation

HRID 1448135 reaction equation
[O:1]([C:8]1[CH:9]=[N+:10]([O-])[CH:11]=[C:12]([N:14]2[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]2)[CH:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:21]CCl.[H][H]>C(O)C.[Pd]>[ClH:21].[O:1]([C:8]1[CH:9]=[N:10][CH:11]=[C:12]([N:14]2[CH2:15][CH2:16][NH:17][CH2:18][CH2:19]2)[CH:13]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

6

Reactant 3

HCID 6344DichloromethaneHCID 70607676HCID 70607676, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 70606969HCID 70606969, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To a solution of 12 g of 3-phenoxy-5-piperazinylpyridine N-oxide and 0.5 g of dichloromethane in 100 ml of ethanol is added 1 g of 20% Palladium on charcoal. The suspension is shaken under a pressure of 50 pounds per square inch of hydrogen atmosphere until no further drop in pressure occurs. The solution is filtered and concentrated in vacuo to give 3-phenoxy-5-piperazinylpyridine monohydrochloride; mp 191°-192.5° C. dec.

Workup

  1. filtrationThe solution is filtered
  2. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-7380dcf3bd8c4c4ab5bbf6928c6db4ab
Source dataset
uspto-grants-1979_12
Patent number
US04179563

Reaction notes

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