Phosphorus oxychloride → HCID 20382044, compound

A solution of 22 g of 3-(p-chlorophenoxy)pyridine N-oxide in 500 ml of chloroform is added dropwise to 77 g of refluxing phosphorous oxychloride. The mixture is refluxed 30 minutes, cooled and concentrated at reduced pressure. The resulting oil is dissolved in 400 ml of dichloromethane, washed with 40 ml ice cold concentrated ammonium hydroxide and the dichloromethane solution is dried over anhydrous MgSO4. The mixture is filtered, concentrated under reduced pressure and distilled to yield the mixture of desired chlorinated pyridines; bp 103°-105° C./0.1 mm. The oil is dissolved in 100 ml of toluene and chromatographed over 400 g of silica gel in toluene to yield in the first eluate, 6-chloro-3-(p-chlorophenoxy)pyridine. Continued elution with toluene yields 2-chloro 3-(p-chlorophenoxy)pyridine. Finally, elution with toluene-methanol (50:50) yields 4-chloro-3-(p-chlorophenoxy)pyridine.

1. temperatureThe mixture is refluxed 30 minutes
2. temperaturecooled
3. concentrationconcentrated at reduced pressure
4. dissolutionThe resulting oil is dissolved in 400 ml of dichloromethane
5. washwashed with 40 ml ice cold concentrated ammonium hydroxide
6. dry with materialthe dichloromethane solution is dried over anhydrous MgSO4
7. filtrationThe mixture is filtered
8. concentrationconcentrated under reduced pressure
9. distillationdistilled
10. customto yield
11. customchromatographed over 400 g of silica gel in toluene

ORD record

ord-3bb12a4fdaa54916acb2cc621ee4c2b8

Source dataset

uspto-grants-1979_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04179563