Hydrochloric Acid → HCID 145793572, compound

HRID 1448367Notes

Reaction equation

[Cl:1][C:2]1C=CC(CC(=N)OCC)=CC=1.Cl.ClC1C=[CH:20][C:19]([CH2:22][C:23]([NH:25][C:26](=[O:32])[NH:27][CH2:28][C:29]([Cl:31])=[O:30])=[NH:24])=CC=1.[OH-].[Na+].Cl.[CH2:36]([CH2:39][O:40][CH3:41])OC>>[ClH:1].[CH3:41][O:40][C:39]1[CH:36]=[CH:2][C:22]([C:23]([NH:25][C:26](=[O:32])[NH:27][CH2:28][C:29]([Cl:31])=[O:30])=[NH:24])=[CH:19][CH:20]=1

Participants

Reactant 5

HCID 313Hydrochloric Acid

HCID 80711,2-Dimethoxyethane

HCID 14798Sodium Hydroxide

HCID 12270047Ethyl 2-(4-chlorophenyl)ethanimidate

HCID 145793576HCID 145793576, compound

Product 1

HCID 145793572HCID 145793572, compound

Procedure

Ethyl 2-(p-chlorophenyl)acetimidate is converted into 2-(3-[2-(p-chlorophenyl)acetimidoyl]ureido)acetyl chloride hydrochloride using the above procedure, except that the hydrolysis step is carried out using 1 N sodium hydroxide and dimethoxyethane (3:1), followed by acidification with 4 N hydrochloric acid.

Workup

customexcept that the hydrolysis step

Sources & evidence

ORD record: ord-58a297bdb0964a379b3fd199577ed86e
Source dataset: uspto-grants-1979_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04179511

Reaction notes

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