Hydrochloric Acid → HCID 70607865, compound

HRID 1448491Notes

Reaction equation

HRID 1448491 reaction equation
[C:1]1([CH:7]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[CH:8]2[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][CH2:16][CH:17]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)O)[CH2:10][CH2:9]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:31]>>[ClH:31].[C:19]1([CH:17]=[CH:16][CH2:15][CH2:14][N:11]2[CH2:12][CH2:13][CH:8]([CH:7]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[CH2:9][CH2:10]2)[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 19937449HCID 19937449, compound

Product 1

HCID 70607865HCID 70607865, compound

Procedure

A mixture of 4-(diphenylmethyl)-α-phenyl-1-piperidinebutanol and 400 ml of 37% HCl was refluxed for 16 hours after which the solvent was removed at reduced pressure. The remaining residue was dissolved in 1 liter of toluene, treated with charcoal and filtered. The filtrate was concentrated to 500 ml, and a solid formed which was recrystallized from butanone and toluene to give the desired product, M.P. 188.5°-209° C.

Workup

  1. temperaturewas refluxed for 16 hours after which the solvent
  2. customwas removed at reduced pressure
  3. dissolutionThe remaining residue was dissolved in 1 liter of toluene
  4. additiontreated with charcoal
  5. filtrationfiltered
  6. concentrationThe filtrate was concentrated to 500 ml
  7. customa solid formed which
  8. customwas recrystallized from butanone and toluene

Sources & evidence

ORD record
ord-2bff404e805a4f698993d18a490ec2b5
Source dataset
uspto-grants-1979_12
Patent number
US04180583

Reaction notes

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