Hydrochloric Acid → HCID 20380007, compound

Participants

Reaction Steps

A mixture of 20 g (0.038 mole) of 4'-bromo-4-[4-(α-hydroxy-α-phenylbenzyl)piperidino]butyrophenone hydrochloride, 500 ml of 37% HCl and 250 ml of n-butanol was refluxed for 3 hours after which the solvent and excess acid were removed under vacuum. The remaining residue was recrystallized from isopropyl alcohol to give the desired product, M.P. 228°-230° C.

Provenance & Evidence