Hydrochloric Acid → HCID 20380007, compound

HRID 1448498Notes

Reaction equation

HRID 1448498 reaction equation
[ClH:1].[Br:2][C:3]1[CH:8]=[CH:7][C:6]([C:9](=[O:33])[CH2:10][CH2:11][CH2:12][N:13]2[CH2:18][CH2:17][CH:16]([C:19](O)([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[CH2:15][CH2:14]2)=[CH:5][CH:4]=1.Cl>C(O)CCC>[ClH:1].[Br:2][C:3]1[CH:8]=[CH:7][C:6]([C:9](=[O:33])[CH2:10][CH2:11][CH2:12][N:13]2[CH2:18][CH2:17][C:16](=[C:19]([C:26]3[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=3)[C:20]3[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=3)[CH2:15][CH2:14]2)=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 20380004HCID 20380004, compound

Product 1

HCID 20380007HCID 20380007, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

A mixture of 20 g (0.038 mole) of 4'-bromo-4-[4-(α-hydroxy-α-phenylbenzyl)piperidino]butyrophenone hydrochloride, 500 ml of 37% HCl and 250 ml of n-butanol was refluxed for 3 hours after which the solvent and excess acid were removed under vacuum. The remaining residue was recrystallized from isopropyl alcohol to give the desired product, M.P. 228°-230° C.

Workup

  1. temperaturewas refluxed for 3 hours after which the solvent and excess acid
  2. customwere removed under vacuum
  3. customThe remaining residue was recrystallized from isopropyl alcohol

Sources & evidence

ORD record
ord-bec80362b7084a39899dccd53430bdb2
Source dataset
uspto-grants-1979_12
Patent number
US04180583

Reaction notes

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