HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4'-tert-Butyl-4-[4-(diphenylmethylene)piperidino]butyrophenone hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | 4'-tert-Butyl-4-(4-(hydroxybenzhydryl)piperidino)butyrophenone | HCID 39380 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | 4'-tert-Butyl-4-[4-(diphenylmethylene)piperidino]butyrophenone hydrochloride | HCID 20379991 | — |
Reaction Steps
A mixture of 30 g (0.059 mole) of 4'-tert-butyl-4-[4-(α-hydroxy-α-phenylbenzyl)piperidino]butyrophenone, 400 ml of 37% HCl, 200 ml of water and 100 ml of n-butanol was refluxed for one and one-half hours after which the solvent and excess acid were removed. The remaining residue was recrystallized from toluene to give the desired product, M.P. 223.5°-225.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04180583 |
| Source dataset | uspto-grants-1979_12 |
| ORD ID | ord-c412664f01134b2db0f43985711b7f01 |
| Source note | uspto-grants-1979_12 |