反应详情

A mixture of 30 g (0.059 mole) of 4'-tert-butyl-4-[4-(α-hydroxy-α-phenylbenzyl)piperidino]butyrophenone, 400 ml of 37% HCl, 200 ml of water and 100 ml of n-butanol was refluxed for one and one-half hours after which the solvent and excess acid were removed. The remaining residue was recrystallized from toluene to give the desired product, M.P. 223.5°-225.5° C.

1. temperaturewas refluxed for one and one-half hours after which the solvent and excess acid
2. customwere removed
3. customThe remaining residue was recrystallized from toluene