Nitric Acid → 3-Bromo-7-hydroxy-2-isopropyl-8-nitro-chromen-4-one

Participants

Reaction Conditions

Reaction Steps

3-Bromo-7-hydroxy-2-isopropyl-chromen-4-one (778 mg, 2.75 mmol) is dissolved in concentrated sulphuric acid (4 ml), and the solution is cooled to 0° C. A solution of fuming nitric acid (189 mg, 3 mmol) in concentrated sulphuric acid (1 ml) is added dropwise. The mixture is stirred at 0° C. for 30 min, poured onto ice, recovered by filtration and dried to give a cream-coloured solid.

Provenance & Evidence